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01/03/2012
Vinco's Smart PS™ - The Smart Choice Vinco's Smart PS™ finished dosage softgels feature an exclusive fluid dispersion phosphatidylserine material that has significantly enhanced stability for maximum brain benefits. Research in animals and humans has shown.....
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01/02/2012
Happy New Year! We, here at Vinco, would like to start off the New Year on the right foot by thanking you for your continued support.
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Resveratrol
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Item# V-RES
60 Softgels per bottle
Dietary Supplement
What is resveratrol?
Resveratrol is a polyphenolic compound found in certain plants that naturally produce it in response to stress, injury, fungal infections, and ultraviolet (UV)
radiation 1. It is a fat-soluble compound that occurs in a trans- and cis- configuration. Both cis- and trans-resveratrol also occur bound to a glucose molecule. 2 The trans-resveratrol is the beneficial component obtained from resveratrol compared to the cis-resveratrol which has no documented benefits.
Obtained from red grapes, Japanese knotweed (polygonum cuspidatum), and other sources, resveratrol may have a host of beneficial health effects such as anti-aging, anti-inflammation, and anti-cancer characteristics. It has also been shown to help prevent the negative effects of high calorie diets in humans, and also has the ability to inhibit platelet aggregation (sticking together). These antioxidant characteristics may help prevent free radical damage to our body and provide protective support to the blood vessels caused particularly by elevated levels of blood glucose.
Vinco’s Resveratrol
We derive the ingredient from the Japanese knotweed, which has been proven to deliver a more stable and balanced consistency and potency of resveratrol over that of red grapes.
Japanese knotweed is a large, herbaceous perennial plant, native to eastern Asia in Japan, China and Korea. In North America and Europe the species is very successful and has been classified as invasive in several countries.
Functions In The Body
Heart and Vessel Health - Inhibition of Vascular Cell Adhesion Molecule Expression
Atherosclerosis is now recognized as an inflammatory disease, and several measures of inflammation are associated with increased risk of myocardial infarction (heart attack) 3. One of the earliest events in the development of atherosclerosis is the recruitment of inflammatory white blood cells from the blood to the arterial wall by vascular cell adhesion molecules 4. Resveratrol has been found to inhibit the expression of adhesion molecules in cultured endothelial cells 5,6.
Heart and Vessel Health - Inhibition of Vascular Smooth Muscle Cell Proliferation
The proliferation of vascular smooth muscle cells plays an important role in the progression of atherosclerosis 7. Resveratrol has been found to inhibit the proliferation of vascular smooth muscle cells in culture 8,9.
Heart and Vessel Health - Inhibition of Platelet Aggregation
Platelet aggregation is one of the first steps in the formation of a blood clot that can occlude a coronary or cerebral artery, resulting in myocardial infarction or stroke, respectively. Resveratrol has been found to inhibit platelet aggregation in vitro 10,11.
Cellular Health and Longevity
Resveratrol helps support and maintain natural cell growth and may act as an anti-aging agent to help increase lifespan. Resveratrol has antioxidant activity.
In some animal models it significantly reduces lipid peroxidation and promotes healthy organ function.
Anti-inflammatory Effects
Inflammation promotes cellular proliferation and angiogenesis and inhibits apoptosis 12. Resveratrol has been found to inhibit the activity of several inflammatory enzymes in vitro, including cyclooxygenase and lipoxygenase 13,14. Resveratrol may also inhibit pro-inflammatory transcription factors, such as NFkB or AP-1 15,16.
Red Wine Extract (Vitis vinifera)
Red Wine Extract is an important source of one of nature's most potent antioxidants, proanthocyanidins. These nutritionally valuable substances have been utilized to treat deteriorating diseases and conditions with great success. Red Wine Extract helps Vitamin C enter the body's cells, thus strengthening the cell membranes and protecting the cells from oxidative damage. Research has shown that proanthocyanidins (which are bioflavonoids) are anti-inflammatory,
antihistamine and antiallergenic, and they are major free radical scavengers. Proanthocyanidins help to promote tissue elasticity, heal injuries, reduce swelling and edema, restore collagen and improve peripheral circulation. The proanthocyanidins in Red Wine Extract also help to prevent bruising, strengthen weak blood vessels, protect against arteriosclerosis and reduce
histamine production. Red Wine Extract strengthens and support cardiovascular function and improves the performance of the nervous system and immune system.
Directions For Use
As a dietary supplement for adults and children twelve or more years of age, take one or two softgels per day, or as directed by a qualified healthcare professional.
References
1. Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, Takada Y. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 2004;24(5A):2783-2840.
2. Romero-Perez AI, Ibern-Gomez M, Lamuela-Raventos RM, de La Torre-Boronat MC. Piceid, the major resveratrol derivative in grape juices. J Agric Food Chem. 1999;47(4):1533-1536.
3. Blake GJ, Ridker PM. C-reactive protein and other inflammatory risk markers in acute coronary syndromes. J Am Coll Cardiol. 2003;41(4 Suppl S):37S-42S.
4. Stocker R, Keaney JF, Jr. Role of oxidative modifications in atherosclerosis. Physiol Rev. 2004;84(4):1381-1478.
5. Carluccio MA, Siculella L, Ancora MA, et al. Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals. Arterioscler Thromb Vasc Biol. 2003;23(4):622-629.
6. Ferrero ME, Bertelli AE, Fulgenzi A, et al. Activity in vitro of resveratrol on granulocyte and monocyte adhesion to endothelium. Am J Clin Nutr. 1998;68(6):1208-1214.
7. Faxon DP, Fuster V, Libby P, et al. Atherosclerotic Vascular Disease Conference: Writing Group III: pathophysiology. Circulation. 2004;109(21):2617-2625. (PubMed)
8. Mnjoyan ZH, Fujise K. Profound negative regulatory effects by resveratrol on vascular smooth muscle cells: a role of p53-p21(WAF1/CIP1) pathway. Biochem Biophys Res Commun. 2003;311(2):546-552. (PubMed)
9. Haider UG, Sorescu D, Griendling KK, Vollmar AM, Dirsch VM. Resveratrol increases serine15-phosphorylated but transcriptionally impaired p53 and induces a reversible DNA replication block in serum-activated vascular smooth muscle cells. Mol Pharmacol. 2003;63(4):925-932.
10. Kirk RI, Deitch JA, Wu JM, Lerea KM. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole blood. Blood Cells Mol Dis. 2000;26(2):144-150. (PubMed)
11. Pace-Asciak CR, Hahn S, Diamandis EP, Soleas G, Goldberg DM. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta. 1995;235(2):207-219.
12. Steele VE, Hawk ET, Viner JL, Lubet RA. Mechanisms and applications of non-steroidal anti-inflammatory drugs in the chemoprevention of cancer. Mutat Res. 2003;523-524:137-144.
13. Donnelly LE, Newton R, Kennedy GE, et al. Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Am J Physiol Lung Cell Mol Physiol. 2004;287(4):L774-783.
14. Pinto MC, Garcia-Barrado JA, Macias P. Resveratrol is a potent inhibitor of the dioxygenase activity of lipoxygenase. J Agric Food Chem. 1999;47(12):4842-4846.
15. Shankar S, Singh G, Srivastava RK. Chemoprevention by resveratrol: molecular mechanisms and therapeutic potential. Front Biosci. 2007;12:4839-4854.
16. de la Lastra CA, Villegas I. Resveratrol as an
anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol Nutr Food Res. 2005;49(5):405-430.
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