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01/03/2012
Vinco's Smart PS™ - The Smart Choice Vinco's Smart PS™ finished dosage softgels feature an exclusive fluid dispersion phosphatidylserine material that has significantly enhanced stability for maximum brain benefits. Research in animals and humans has shown.....
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01/02/2012
Happy New Year! We, here at Vinco, would like to start off the New Year on the right foot by thanking you for your continued support.
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Magnesium Malate
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Item # V-MALIC
90 capsules per bottle
Dietary Supplement
Overview
Magnesium is an essential mineral needed by every cell of your body to help maintain normal cardiovascular, muscle, nerve, bone, and cellular function. Magnesium Malate is a highly absorbable form of magnesium that provides the benefits of this mineral, along with the benefits of malic acid, a nutrient found to contribute to the process of transforming food into ATP, the body's energy source. Magnesium Malate is one of the few substances that can chelate aluminum from tissues of the body. Because malic acid plays a key role in the production of energy in the mitochondria, it is often recommended with magnesium for fibromyalgia and chronic fatigue syndrome.
Clinical Applications
Fibromyalgia - meaning muscle and connective tissue pain (also referred to as FM or FMS), is a medically unexplained syndrome[1][2][3] characterized by chronic widespread pain and a heightened and painful response to pressure (allodynia).[4] Other core symptoms are debilitating fatigue, sleep disturbance, and joint stiffness. Some patients[5] may also report difficulty with swallowing,[6] bowel and bladder abnormalities,[7] numbness and tingling (paresthesia),[8] and cognitive dysfunction.[9]
Chronic Fatigue Syndrome (CFS) is the most common name[10] given to an inadequately understood, variably debilitating disorder or disorders characterized by medically unexplained symptoms.[11] It is also commonly known as myalgic encephalomyelitis. Symptoms of CFS include widespread muscle and joint pain, cognitive difficulties, chronic, often severe mental and physical exhaustion and other characteristic symptoms in a previously healthy and active person. Fatigue is a common symptom in many illnesses, but CFS is a multi-systemic disease and is relatively rare by comparison.[12] Diagnosis requires a number of features the most common being severe mental and physical exhaustion which is "unrelieved by rest", is worsened by exertion and is present for at least six months. All diagnostic criteria require that the symptoms must not be caused by other medical conditions. CFS patients may report additional symptoms [13] including muscle weakness, cognitive dysfunction, hypersensitivity, orthostatic intolerance, digestive disturbances, depression, poor immune response, cardiac and respiratory problems.
Oxidative Stress - is caused by an imbalance between the production of reactive oxygen and a biological system's ability to readily detoxify the reactive intermediates or easily repair the resulting damage. All forms of life maintain a reducing environment within their cells. This reducing environment is preserved by enzymes that maintain the reduced state through a constant input of metabolic energy. Disturbances in this normal redox state can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA.
Osteoarthritis - (OA, also known as degenerative arthritis, degenerative joint disease), is a group of diseases and mechanical abnormalities entailing degradation of joints,[14] including articular cartilage and the subchondral bone next to it. Clinical symptoms of OA may include joint pain, tenderness, stiffness, inflammation, creaking, and locking of joints. In OA, a variety of potential forces—hereditary, developmental, metabolic, and mechanical—may initiate processes leading to loss of cartilage -- a strong protein matrix that lubricates and cushions the joints. As the body struggles to contain ongoing damage, immune and regrowth processes can accelerate damage.[15]
A Malic A Day …
That 'ol achy feelin'
The morning after. We spent all weekend working on the yard, moving furniture and had that softball marathon. Now it's Monday and we can't get out of bed. Our muscles are tight, out joints are sore, we've overdone it and now we are in pain.
At one time or another we have all experienced this sort of thing, some more than others, and have tried to deal with it the best we can. But now, an ingredient found in apples, Malic acid, may help alleviate this pain - before it starts.
As the body's network of muscles need more energy (during exercise or hard work), there is a higher demand for glucose (blood sugar). Sometimes, when the breakdown of glucose can't keep up with the body's need for energy, lactic acid is formed. The more lactic build-up there is in muscle tissues, the more pain we feel afterwards.
But Malic Acid can help. Studies have shown that this acid can reduce excess lactic acid by acting as a catalyst for the body's chief energy system - the Krebs Cycle. When more glucose products make it to the Krebs Cycle, the more energy will be obtained and the less residual pain.
Vinco’s Magnesium Malate is an excellent, bioavailable form of Magnesium. Malic Acid, Magnesium, and Thiamine have been associated with a reduction in chronic muscle soreness, tiredness, and fatigue.
Directions for Use: As a dietary supplement for adults and children twelve or more years of age, take one capsule three times per day, or as directed by a qualified healthcare professional.
References
[1] Richardson, Rd; Engel, Cc, Jr (Jan 2004). "Evaluation and
management of medically unexplained physical symptoms". The
neurologist 10 (1): 18–30.
[2] Deary V, Chalder T, Sharpe M (October 2007). "The cognitive
behavioural model of medically unexplained symptoms: a
theoretical and empirical review". Clin Psychol Rev 27 (7): 781–97.
[3] Nimnuan C, Hotopf M, Wessely S (2001). "Medically unexplained symptoms: an epidemiological study in seven specialities". J Psychosom Res 51: 361–7.
[4] Wolfe F, Smythe HA, Yunus MB et al. (February 1990). "The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee". Arthritis Rheum. 33 (2): 160–72.
[5] Wolfe F (February 1989). "Fibromyalgia: the clinical syndrome". Arthritis Rheum. 15 (1): 1–18.
[6] Wallace DJ, Hallegua DS. (October 2002). "Fibromyalgia: the
gastrointestinal link.". Curr Pain Headache Rep. 8 (5): 64–8.
[7] Clauw DJ, Schmidt M, Radulovic D, Singer A, Katz P, Bresette J.
(Jan-February 1997). "The relationship between fibromyalgia and interstitial cystitis.". J Psychiatr Res. 31 (1): 125–31.
[8] Simms RW, Goldenberg DL. (August 1988). "Symptoms mimicking neurologic disorders in fibromyalgia syndrome.". J Rheumatol. 15 (8): 1271–3.
[9] Glass JM. (December 2006). "Cognitive dysfunction in fibromyalgia and chronic fatigue syndrome: new trends and future directions.".
Curr Rheumatol Rep. 8 (6): 425–9
[10] Evangard B, Schacterie R.S., Komaroff A. L. (1999). "Chronic fatigue syndrome: new insights and old ignorance". Journal of Internal Medicine Nov;246 (5): 455–469.
[11] Deary V, Chalder T, Sharpe M (October 2007). "The cognitive behavioural model of medically unexplained symptoms: a theoretical and empirical review". Clin Psychol Rev 27 (7): 781–97. doi:10.1016/j.cpr.2007.07.002. PMID 17822818.
[12] Ranjith G (2005). "Epidemiology of chronic fatigue syndrome.". Occup Med (Lond) 55 (1): 13–29. doi:10.1093/occmed/kqi012. PMID 15699086.
[13] Wyller VB (2007). "The chronic fatigue syndrome--an update". Acta neurologica Scandinavica. Supplementum 187: 7–14.
[14] Osteoarthritis at Dorland's Medical Dictionary
[15] Brandt, Kenneth D.; Dieppe, Paul; Radin, Eric (2008). "Etiopathogenesis of Osteoarthritis". Med Clin N Am 93: 1–24.
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