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01/03/2012
Vinco's Smart PS™ - The Smart Choice Vinco's Smart PS™ finished dosage softgels feature an exclusive fluid dispersion phosphatidylserine material that has significantly enhanced stability for maximum brain benefits. Research in animals and humans has shown.....
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01/02/2012
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CoQ-Complete® 100
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Item# V-COQ100
30 Softgels per bottle
Dietary Supplement
The Crucial Nature of CoQ10
Coenzyme-Q10 (CoQ10) is a vitamin-like substance found in virtually all cells of the human body, including the heart, liver, and skeletal muscles, and in most plant and animal cells.
• As an antioxidant, CoQ10 protects proteins, LD (“bad”) cholesterol, and mitochondrial DNA from oxidative damage.
• As a participant in the production of cellular energy, CoQ10 helps ensure the body’s biggest energy consumers - the heart and the brain - are well-fed.
Thanks to these two crucial functions, CoQ10 can lower blood pressure, enhance cardiac function in patients with cardiomyopathy, improve symptoms of congestive heart failure, relieve angina, and increase recovery from heart attack. Additionally, it may slow the progression and improve the symptoms of neurodegenerative diseases such as Parkinson’s disease. Of course, none of these benefits can be realized if CoQ10 isn’t absorbed and research indicates that the body uptakes only a small fraction of traditional powder-based (crystalline) CoQ10.
The CoQ10 Absorption Dilemma
In order to be absorbed, all nutrients must first be in a water-soluble form. Unfortunately, because of its structure, CoQ10 is highly lipophilic (fat-loving) and practically insoluble in water. This lipophilic nature makes CoQ10’s absorption:
• Poor: Less than 6% of orally administered CoQ10 permeates the
gastro-intestinal tract into the blood.
• Highly variable: Some individuals absorb considerably less CoQ10 than others.
• Strongly dependent on stomach contents: Foods rich in fat enhance absorption.
Making matters worse, CoQ10 is a large molecule, contributing to its poor absorption. Plus, when CoQ10 is produced commercially, crystals are formed that melt when they reach 118°F or 48°C. Upon cooling, CoQ10 recrystallizes, which frequently results in even larger crystals and further lowers CoQ10 bioavailability.
The Crystal-Free CoQ10 Solution
In order to improve bioavailability, some manufacturers have sought to reduce the particle size of CoQ10, thus increasing its surface area. Suspending fine particles in an emulsion or paste is an effective means of increasing bioavailability. However, there is an even more effective solution: achieving complete solubility.
Introducing CoQ-Complete®, a completely soluble, liquid, crystal-free solution of CoQ10 clinically proven to provide superior bioavailability of this key nutrient.
CoQ-Complete® is a unique, patent-pending formulation of CoQ10, d-Limonene, and natural tocopherols (vitamin E). Upon microscopic examination at 200x, a paste of CoQ10 powder and soybean oil exhibits a crystalline structure, while CoQ-Complete® is completely devoid of crystals because the CoQ10 has been solubilized.
CoQ-Complete® Trio of Ingredients
• CoQ10: CoQ10 functions as a carrier to transfer electrons across the membrane of the mitochondria, the energy-producing “factories” within cells, to drive production of adenosine triphosphate (ATP), or cellular energy. Heart muscles have the greatest concentration of mitochondria, 5,000 per cell, which is one reason why CoQ10 is so important for cardiovascular function.
In its reduced form, ubiquinol, CoQ10 acts as an antioxidant to protect proteins, LDL (“bad”) cholesterol, and mitochondrial DNA from oxidative damage. Research has shown that CoQ10 supplementation exerts a sparing effect on vitamin E in healthy subjects, helping to maintain its antioxidant state. It also reduces levels of lipid peroxidation, the pivotal reaction in the cause of atherosclerosis, and thus reduces the risk of cardiovascular disease.
• d-Limonene: Extracted from the oil of citrus fruits, food-grade d-Limonene acts as a non-polar organic solvent that solubilizes CoQ10, without causing significant chemical interactions or degradation.1 The end result is a liquid, crystal-free, completely soluble CoQ10, providing superior bioavailability, that does not require heat or synthetic, chemical solvents and that fully resists recrystallization at ambient temperatures.
• Tocopherols: A form of vitamin E, tocopherols enhance the biological function of CoQ10, which in turn helps maintain the antioxidant state of vitamin E.
Proof of Bioavailability -
Particle Size Analysis
Investigators at the third-party laboratory Particle Technology Labs, Inc. performed particle size analysis on CoQ-Complete® using a variety of methods:
• High-intensity microscope light. A sample of CoQ-Complete® was placed into a clear glass vial. When a high-intensity microscope light was directed through the container, no scattered light was observed, due to near sub-micron particulate matter.
• 100x dark field microscope. A sample of CoQ-Complete® was placed under a 100x dark field microscope, which is able to detect the presence of very small particles. There was no evidence of large crystalline, nor of near-micron sized, particulate matter.
• Instrumental analysis. A sample of CoQ-Complete® was placed into several instruments able to detect particulate material down to at least 1 part per million. No submicron particulate was detected.
in-vivo Research
“Bioavailability and Tissue Distribution of Soluble vs. Powdered Coenzyme-Q10”
An in vivo study was undertaken to compare the bioavailability and tissue distribution of various forms of CoQ10. Forty eight male mice were randomly assigned to four treatment groups: 1. CoQ-Complete®, 2. CoQ10 Standard, 3. Powdered CoQ10, or 4. Placebo. Each group received the treatment by gavage for 4 weeks. The study yielded the following results:
• Overall concentration of CoQ10 was highest in the CoQ-Complete® group.
• Treatment with CoQ-Complete® resulted in accumulation of CoQ10 in the serum, heart, and liver, the normal CoQ10 storage organs, suggesting the
best bioavailability.
• ~ 20% more CoQ10 was available in the hearts of mice treated with CoQ-Complete® compared to other treatment groups.
• ~ 18% more CoQ10 was available in the livers of mice treated with CoQ-Complete® compared to other treatment groups.
“We were taken by the fact that the fluid was sparkling clean to the naked eye under a high-intensity light beam.”
- Investigators at the 3rd party laboratory
Particle Technology Labs, Inc.
Human Clinical Research
“Bioavailability and Health Effects of CoQ10 in Healthy Human Adults”
A double-blind, randomized, parallel group human clinical trial was undertaken to compare the oral bioavailability of CoQ-Complete® versus standard, commercial grade Powdered CoQ10 in 30 healthy subjects over a period of 28 days. Compared to supplementation with standard Powdered CoQ10, supplementation with CoQ-Complete® resulted in:
• Significantly greater uptake of CoQ10.
• Significantly increased plasma CoQ10 levels by the end of the treatment period.
• Significantly higher post-treatment oral bioavailability of CoQ10.
• Significantly higher retention of plasma CoQ10 levels above baseline up to 6 days post-treatment.
“Peak Absorption Characteristics and Steady State Bioavailability of a Cold Soluble CoQ10 Product”
A pilot clinical trial was undertaken to determine the single-dose peak absorption characteristics and the 28-day steady state bioavailability of CoQ-Complete® in 5 normal volunteers.
Peak Absorption Study: Volunteers took 60 mg CoQ-Complete®, followed by a breakfast of orange juice or milk with a bagel or cereal.
• 4 hours after ingesting the supplement, group plasma CoQ10 levels increased significantly from 0.88 µg/ml (baseline) to 1.36 µg/ml.
• Peak plasma levels occurred at 6 hours (Tmax) and the maximum plasma concentration (Cmax) was 2.28 µg/ml.
• The amount of CoQ10 absorbed at Cmax was 4,769.5 µg/ml, or 7.96% of the ingested dose, significantly higher than most forms of CoQ 10.
Steady State Plasma CoQ10 Bioavailability
Volunteers continued taking 60 mg CoQ-Complete® daily with breakfast for 28 days.
• At 7 days, the mean plasma CoQ10 level had increased to 2.39 µg/ml.
• At 14 days, the mean plasma CoQ10 level had increased to 2.68 µg/ml.
• At 28 days, the mean plasma CoQ10 level had reached 2.75 µg/ml. This means that in just 4 weeks, the mean CoQ10 plasma level increased by 200%.
Indications
Cardiovascular Wellness
Thanks to its function as an antioxidant and its role in the production of cellular energy, supplemental CoQ10 has been shown to benefit patients with cardiovascular diseases, including:
• Hypertension (high blood pressure): A pilot study showed that in patients with hypertension, CoQ10 supplementation led to statistically significant decreases in systolic and diastolic blood pressure. 2
• Congestive heart failure (a disease in which the heart does not adequately maintain circulation): At least five double-blind, placebo-controlled trials have found that CoQ10 significantly reduces the severity of symptoms in congestive heart failure patients. 3
• Cardiomyopathy (heart muscle disease): Two studies have yielded very positive results in treating cardiomyopathy with CoQ10. In each study, over 80% of patients showed significant improvements in cardiac function. 4
• Angina pectoris (chest pain): Several small trials have shown that CoQ10 supplementation decreases angina episodes and increases exercise capacity. 5,6
• Heart attack recovery: A double-blind trial found that heart attack survivors who supplemented with CoQ10 for 28 days afterwards experienced fewer heart-related problems than those who took placebo. 7
CoQ10 supplementation has also been demonstrated to prevent the plasma CoQ10 decrease caused by the statin drug simvastatin, without affecting its cholesterollowering effect. 8
Brain Wellness
There is substantial evidence that oxidative damage and mitochondrial dysfunction may play a key role in the pathogenesis of neurodegenerative diseases, including:
• Parkinson’s disease. Two trials have indicated that CoQ10 supplementation may slow the progression of Parkinson’s 9 and produce a mild improvement in
symptoms. 10
• Alzheimer’s disease. While no clinical trials have been published on CoQ10 and Alzheimer’s disease, researchers at a 2004 meeting of Academy Health did note that: “Because mitochondrial dysfunction has been postulated in AD, a randomized controlled trial of CoQ10 appears warranted.” 11
Highlights
CoQ-Complete® is a completely soluble, 100% crystal-free formulation clinically proven to provide superior bioavailability of CoQ10.
CoQ-Complete® includes the following trio of ingredients:
• CoQ10. CoQ10 serves two main functions in the body. As an antioxidant, CoQ10 protects proteins, LDL (“bad”) cholesterol, and mitochondrial DNA from oxidative damage. As a participant in the production of cellular energy, CoQ10 helps ensure the body’s biggest energy consumers, the heart and the brain, are well-fed.
• d-Limonene. Extracted from the oil of citrus fruits, food-grade d-Limonene acts as a non-polar organic solvent that solubilizes CoQ10, without causing significant chemical interactions or degradation.
• Tocopherols. A form of vitamin E, tocopherols enhance the biological function of CoQ10, which in turn helps maintain the antioxidant state of vitamin E.
References
1. Palamakula A, et al. Preparation and in vitro characterization of self-nanoemulsified drug delivery systems of coenzyme Q10 using chiral essential oil components. Pharm Tech. 2004; 74.
2. Yamagami T, et al. Bioenergetics in clinical medicine. Studies on coenzyme Q10 and essential hypertension. Res Commun Chem Pathol Pharmacol. 1975; 11:273.
3. EBSCO Publishing. “Congestive Heart Failure.” Consumerlab.com. Accessed June 9, 2009. http://www.consumerlab.com/tnp.asp?chunkiid=21583#ref2
4. EBSCO Publishing. “Cardiomyopathy.” Consumerlab.com. Accessed June 9, 2009. http://www.consumerlab.com/tnp.asp?chunkiid=21484#ref1
5. Kamikawa T, et al. Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris. Am J Cardiol. 1985 Aug 1;56(4):247-51.
6. Wilson, MR, et al. Coenzyme Q10 therapy and exercise duration in stable angina. In: Folkers, K., Littami, GP, Yamogami, T (eds), Biomedical and Clinical Aspects of Coenzyme Q10, vol. 6, Amsterdam. Elsevier;1991:339-348.
7. Singh RB, et al. Randomized double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. Cardiovasc Drugs Ther. 1998;12:347-353.
8. Bargossi AM et al. Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors. Mol Aspects Med. 1994; 15:S187.
9. Shults CW, et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol. 2002;59:1541-1550.
10. Muller T, et al. Coenzyme Q(10) supplementation provides mild symptomatic benefit in patients with Parkinson’s disease. Neurosci Lett. 2003;341:201-204.
11. Young AJ, et al. Coenzyme Q10: A Promising Treatment for Alzheimer’s Disease? Abstr AcademyHealth Meet. 2004; 21: abstract no. 1715.
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